Route Map
Price Drops & Deals
21-Day Panama Canal
Holland America LineCompare Cruise Lines
| Cruise Line | Cruises | Ships | From | Duration | Next Sailing | |
|---|---|---|---|---|---|---|
|
Holland America Line
|
5 | 2 | $2,909 | 20-22 nights | Sep 27, 2026 |
All Cruises on This Route
- 21-night Holland America Line cruise on Nieuw Amsterdam from Vancouver, British Columbia
- 20-night Holland America Line cruise on Eurodam from Vancouver, British Columbia
- 21-night Holland America Line cruise on Nieuw Amsterdam from Fort Lauderdale, Florida
- 22-night Holland America Line cruise on Eurodam from Fort Lauderdale, Florida
Ports on This Route
Puerto Quetzal
Hike through misty highlands to discover colorful Mayan villages and volcanic landscapes that feel worlds away from the cruise ship.
San Diego, California
Explore the USS Midway Museum, a colossal aircraft carrier transformed into a fascinating naval history adventure.
Puntarenas
Zip through misty cloud forests and spot sloths, toucans, and howler monkeys in their natural habitat.
Puerto Vallarta
Wander through colorful colonial streets lined with galleries and shops, then relax on pristine beaches backed by lush tropical mountains.
Acajutla
Kayak through mangrove forests teeming with wildlife and relax on pristine black sand beaches backed by volcanic mountains.
Cartagena
Wander through centuries-old Mediterranean architecture while savoring fresh seafood in charming plazas overlooking pristine beaches.
Puerto Chiapas
Discover pristine Pacific beaches and lush mangrove ecosystems teeming with exotic wildlife and colorful bird species.
Acapulco
Watch fearless cliff divers plunge 130 feet into shimmering waters at La Quebrada, Acapulco's most iconic and thrilling spectacle.
Cabo San Lucas
Witness the dramatic clash of the Pacific Ocean and Sea of Cortez at El Arco, a stunning natural rock formation that defines Cabo's rugged coastal beauty.
Huatulco (Santa María Huatulco)
Glide through nine pristine bays with crystalline waters perfect for snorkeling and spotting tropical fish in this undiscovered Pacific paradise.
San Francisco, California
Ride the iconic cable cars up steep hills to glimpse the Golden Gate Bridge and Victorian architecture in one unforgettable journey.
Aruba
Wade through turquoise shallows to pristine beaches and colorful shipwrecks that make Aruba's calm waters a snorkeler's paradise.
Santa Barbara, California
Stroll the iconic Santa Barbara Mission and pier then soak in Mediterranean charm through Spanish colonial architecture and world-class wine country just minutes away.
Fuerte Amador
Explore the Panama Canal's engineering marvel while island-hopping through pristine waters and discovering colorful marine life in this tropical paradise.
Half Moon Cay
Swim alongside friendly dolphins and lounge on pristine pink-sand beaches in this exclusive island paradise.
Manzanillo, Mexico
Discover pristine beaches backed by lush jungle where you can zip-line through canopy and relax in natural hot springs.
Victoria, British Columbia
Explore the stunning Butchart Gardens, where fifty acres of meticulously designed floral landscapes transform across the seasons.